Talaat Lab

Publications

Highlighted below are the publications of the last 5 years – including those addressing SARS-CoV-2 immune response studies and the genomic analysis of drug-resistant tuberculosis. For a full list of publications, visit Adel Talaat’s authorship on PubMed.

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2023

  • A DNA Prime and MVA Boost Strategy Provides a Robust Immunity Against Infectious Bronchitis Virus in Chickens PMID: 36851180

  • Characterization of early immune responses elicited by live and inactivated vaccines against Johne’s disease in goats PMID: 36699320

  • Protective RNA nanovaccines against Mycobacterium avium subspecies hominissuis LINK: https://pubmed.ncbi.nlm.nih.gov/37359562/

  • The Immunogenicity and Safety of Mycobacterium tuberculosis– mosR-Based Double Deletion Strain in Mice LINK: https://pubmed.ncbi.nlm.nih.gov/37630665/

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2022

  • Transcriptional Profiling of Early and Late Phases of Bovine Tuberculosis PMID: 34898250
  • Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2 PMID: 35746733
  • Vaccine-induced systemic and mucosal T cell immunity to SARS-CoV-2 viral variants PMID: 35561224

  • Superinfection with SARS-CoV-2 Has Deleterious Effects on Mycobacterium bovis BCG Immunity and Promotes Dissemination of Mycobacterium tuberculosis PMID: 36200898

2021

  • Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal Immunization PMID: 33562141
  • Genotypic analysis of nontuberculous mycobacteria isolated from raw milk and human cases in Wisconsin PMID: 33162087
  • Uncovering the role of CBLB for innate immune responses regulating systemic dissemination during a Non-Tuberculous Mycobacterial infection LINK

2020

  • A Protective Vaccine against Johne’s Disease in Cattle PMID: 32957508
  • A Novel Mucosal Adjuvant System for Immunization against Avian Coronavirus Causing Infectious Bronchitis PMID: 32669327
  • A single dose polyanhydride-based nanovaccine against paratuberculosis infection PMID: 32128256

2019

  • Genomic analysis of the emergence of drug-resistant strains of Mycobacterium tuberculosis in the Middle East PMID: 31882574
  • Genomic Polymorphism Associated with the Emergence of Virulent Isolates of Mycobacterium bovis in the Nile Delta PMID: 31406159
  • Effective mosaic-based nanovaccines against avian influenza in poultry PMID: 31300285
  • The inhibitory effect of nisin on Mycobacterium avium ssp. paratuberculosis and its effect on mycobacterial cell wall PMID: 30981481
  • Genomic analysis of the emergence of drug-resistant strains of Mycobacterium tuberculosis in the Middle East PMID: 30872748

2018

  • Biomarkers for Early Stages of Johne’s Disease Infection and Immunization in Goats PMID: 30323794

2017

  • Viable Mycobacterium avium ssp. paratuberculosis isolated from calf milk replacer PMID: 28987590
  • Superior Protection from Live-Attenuated Vaccines Directed against Johne’s Disease PMID: 27806993

Patents

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Immunogenic compositions against tuberculosis

  • US10786559B2. Adel M. Talaat, Sarah K. Ward, Bassam Abomoelak. Issued (2020)
    • Continuation of US20160175420A1
  • US9220764B2. Adel M. Talaat, Sarah K. Ward, Bassam Abomoelak. Issued (2015)
    • Continuation of US8367055B2
  • US8367055B2. Adel M. Talaat, Bassam Abomoelak, Sarah K. Ward. Active (2013)

Vaccine candidates against Johne’s disease

  • US20190314478A1. Adel M. Talaat. Pending (2019)
    • Divisional of US20180147272A1
  • US9855323B2. Adel M. Talaat. Issued (2018)
    • Continuation of US9446110B2
  • US9446110B2. Adel M. Talaat. Issued (2016)
    • Continuation of US8758773B2
  • US8758773B2. Adel M. Talaat. Issued (2014)

Global gene regulators (GGR) as vaccine candidates against paratuberculosis

  • US20210246416A1. Adel M. Talaat. Pending (2021)
    • Divisional of US10544389B2
  • US10968425B2. Adel M. Talaat. Issued (2021)
    • Divisional of US10544389B2
  • US10544389B2. Adel M. Talaat. Issued (2020)
    • Continuation of US9663758B2
  • US9663758B2. Adel M. Talaat. Issued (2017)

Biomarkers for early diagnosis and differentiation of mycobacterial infection

Novel adjuvant for animal and human vaccines

Neutralizing vaccines against human coronavirus

A universal vaccine against Infectious Bronchitis Virus, Avian Influenza, Newcastle Disease Virus and Infectious Bursal Disease

  • WARF: P190239US01. Adel M. Talaat and Brock Bakke. Pending

Modified Gene Vaccines Against Avian Coronavirus

  • WARF: P210169. Adel M. Talaat and Sekar Chandrasekar. Pending